抑製劑ARN 272，CAS:488793-85-7
FAAH樣anandamide轉運蛋白（FLAT）抑製劑（IC50 = 1.8μM）; 結合anandamide的FAAH-1的胞質變體(ti) 。 分別在體(ti) 外和體(ti) 內(nei) 減輕anandamide內(nei) 化和失活。 在CB1介導的傷(shang) 害性和炎性疼痛的齧齒動物模型中展現止痛作用。
| M. Wt | 432.47 |
| Formula | C27H20N4O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 488793-85-7 |
| PubChem ID | 24802717 |
| InChI Key | YNADXFWEXJTQSZ-UHFFFAOYSA-N |
| Smiles | OC(C=C4)=CC=C4C2=NN=C(NC3=CC=C(C(NC5=CC=CC=C5)=O)C=C3)C1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 | |
| ethanol | 8.65 | 20 |
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